Best Poison Champions in MCOC

28 champions can inflict Poison, sorted by their place on the combined tier list so the strongest come first. Updated November 2026. Fighting a Poison champion? See who is immune to Poison.

S+ Tier 4

  1. 2ArchangelS+100
  2. 6Doctor StrangeS+100
  3. 15Nico MinoruS+100
  4. 29Jack O'LanternS+96

S Tier 1

  1. 38ScorpionS95

B Tier 3

  1. 141Black Widow (Claire Voyant)B64
  2. 154Spider-Man 2099B64
  3. 163DiabloB60

C Tier 10

  1. 171ApocalypseC59
  2. 172ArcadeC59
  3. 182Abomination (Immortal)C58
  4. 183Cassie LangC58
  5. 193GorrC54
  6. 216Doctor VoodooC50
  7. 218Man-ThingC50
  8. 223Scarlet WitchC49
  9. 226EnchantressC46
  10. 233Scarlet Witch (Classic)C46

D Tier 6

  1. 237MysterioD45
  2. 253King GrootD39
  3. 260M.O.D.O.K.D36
  4. 263ToadD36
  5. 270Ant-ManD32
  6. 272HawkeyeD32

F Tier 4

  1. 307AbominationF20
  2. 328Ultron (Classic)F20
  3. 332KravenF19
  4. 335Green GoblinF18

Other debuffs: Armor Break · Armor Shattered · Bleed · Coldsnap · Concussion · Degeneration · Delirium · Disorient · Enervate · Exhaustion · Falter · Fate Seal · Fatigue · Frostbite · Heal Block · Incinerate · Neutralize · Nova Flame · Nullify · Petrify · Plasma · Power Burn · Power Drain · Power Lock · Power Sting · Rupture · Sabotage · Shock · Sleep · Slow · Stagger · Stun · Taunt · Weakness