Best Neutralize Champions in MCOC

8 champions can inflict Neutralize, sorted by their place on the combined tier list so the strongest come first. Updated November 2026.

S+ Tier 2

  1. 6Doctor StrangeS+100
  2. 19Spider-Man (Pavitr Prabhakar)S+100

S Tier 1

  1. 46TigraS92

A Tier 1

  1. 100VoxA78

B Tier 1

  1. 153RintrahB64

C Tier 2

  1. 221WiccanC50
  2. 226EnchantressC46

D Tier 1

  1. 256Guillotine (Deathless)D38

Other debuffs: Armor Break · Armor Shattered · Bleed · Coldsnap · Concussion · Degeneration · Delirium · Disorient · Enervate · Exhaustion · Falter · Fate Seal · Fatigue · Frostbite · Heal Block · Incinerate · Nova Flame · Nullify · Petrify · Plasma · Poison · Power Burn · Power Drain · Power Lock · Power Sting · Rupture · Sabotage · Shock · Sleep · Slow · Stagger · Stun · Taunt · Weakness