Best Fatigue Champions in MCOC

8 champions can inflict Fatigue, sorted by their place on the combined tier list so the strongest come first. Updated November 2026.

A Tier 1

  1. 111TitaniaA74

B Tier 1

  1. 136VoidB68

C Tier 3

  1. 186ColossusC56
  2. 230Mister NegativeC46
  3. 233Scarlet Witch (Classic)C46

D Tier 2

  1. 260M.O.D.O.K.D36
  2. 270Ant-ManD32

F Tier 1

  1. 310Captain AmericaF20

Other debuffs: Armor Break · Armor Shattered · Bleed · Coldsnap · Concussion · Degeneration · Delirium · Disorient · Enervate · Exhaustion · Falter · Fate Seal · Frostbite · Heal Block · Incinerate · Neutralize · Nova Flame · Nullify · Petrify · Plasma · Poison · Power Burn · Power Drain · Power Lock · Power Sting · Rupture · Sabotage · Shock · Sleep · Slow · Stagger · Stun · Taunt · Weakness