Best Degeneration Champions in MCOC

47 champions can inflict Degeneration, sorted by their place on the combined tier list so the strongest come first. Updated November 2026.

S+ Tier 5

  1. 11KnullS+100
  2. 12KushalaS+100
  3. 13Madelyne PryorS+100
  4. 14Mister SinisterS+100
  5. 17OnslaughtS+100

S Tier 3

  1. 34Captain BritainS95
  2. 45KingpinS92
  3. 51MojoS91

A Tier 5

  1. 72Ghost RiderA82
  2. 82Spider-Slayer (J. Jonah Jameson)A82
  3. 95PurgatoryA78
  4. 100VoxA78
  5. 117WarlockA72

B Tier 8

  1. 122Blade (Stellar Forge)B68
  2. 128KindredB68
  3. 130Omega RedB68
  4. 136VoidB68
  5. 146LongshotB64
  6. 158UltronB64
  7. 159GamoraB61
  8. 165Guillotine 2099B60

C Tier 14

  1. 171ApocalypseC59
  2. 174Elsa BloodstoneC59
  3. 179MaestroC59
  4. 191Venom the DuckC55
  5. 193GorrC54
  6. 197MordoC54
  7. 200The LeaderC54
  8. 201Thor (Jane Foster)C54
  9. 211VenompoolC51
  10. 213CableC50
  11. 221WiccanC50
  12. 223Scarlet WitchC49
  13. 229Magneto (House of X)C46
  14. 230Mister NegativeC46

D Tier 11

  1. 240DraculaD42
  2. 241Dragon ManD42
  3. 246The DestroyerD42
  4. 250GuillotineD40
  5. 252RogueD40
  6. 255Vision (Deathless)D39
  7. 256Guillotine (Deathless)D38
  8. 259IsophyneD36
  9. 271Ebony MawD32
  10. 274SauronD32
  11. 286PsylockeD30

F Tier 1

  1. 295DormammuF26

Other debuffs: Armor Break · Armor Shattered · Bleed · Coldsnap · Concussion · Delirium · Disorient · Enervate · Exhaustion · Falter · Fate Seal · Fatigue · Frostbite · Heal Block · Incinerate · Neutralize · Nova Flame · Nullify · Petrify · Plasma · Poison · Power Burn · Power Drain · Power Lock · Power Sting · Rupture · Sabotage · Shock · Sleep · Slow · Stagger · Stun · Taunt · Weakness