Best Power Drain Champions in MCOC

43 champions can inflict Power Drain, sorted by their place on the combined tier list so the strongest come first. Updated November 2026. Fighting a Power Drain champion? See who is immune to Power Drain.

S+ Tier 2

  1. 20Spider-Man (Stark Enhanced)S+100
  2. 26Cosmic Ghost RiderS+96

S Tier 5

  1. 39SolvarchS95
  2. 49Ant-Man (Future)S91
  3. 50IronheartS91
  4. 52ProwlerS91
  5. 60NimrodS86

A Tier 3

  1. 73GuardianA82
  2. 104Red SkullA76
  3. 117WarlockA72

B Tier 6

  1. 127Iron ManB68
  2. 131Omega SentinelB68
  3. 135Viv VisionB68
  4. 144HulkbusterB64
  5. 165Guillotine 2099B60
  6. 167NamorB60

C Tier 9

  1. 173Captain America (Sam Wilson)C59
  2. 181SasquatchC59
  3. 184Corvus GlaiveC58
  4. 195ImperiosaC54
  5. 222Punisher 2099C49
  6. 224Star-LordC48
  7. 226EnchantressC46
  8. 232NebulaC46
  9. 233Scarlet Witch (Classic)C46

D Tier 9

  1. 237MysterioD45
  2. 239Doctor OctopusD42
  3. 244Rocket RaccoonD42
  4. 245TerraxD42
  5. 272HawkeyeD32
  6. 273Iron Man (Infinity War)D32
  7. 276VultureD32
  8. 280Air-WalkerD30
  9. 286PsylockeD30

F Tier 9

  1. 292MephistoF28
  2. 294Civil WarriorF26
  3. 295DormammuF26
  4. 299Red GoblinF26
  5. 300Silver CenturionF26
  6. 322KangF20
  7. 326Psycho-ManF20
  8. 330Winter SoldierF20
  9. 335Green GoblinF18

Other debuffs: Armor Break · Armor Shattered · Bleed · Coldsnap · Concussion · Degeneration · Delirium · Disorient · Enervate · Exhaustion · Falter · Fate Seal · Fatigue · Frostbite · Heal Block · Incinerate · Neutralize · Nova Flame · Nullify · Petrify · Plasma · Poison · Power Burn · Power Lock · Power Sting · Rupture · Sabotage · Shock · Sleep · Slow · Stagger · Stun · Taunt · Weakness