Champions Immune to Poison in MCOC

65 champions are immune to Poison, sorted by their place on the tier list so the best options come first. 4 of them are only immune under a condition, such as a mode or an ability being active. Updated November 2026.

S+ Tier 6

  1. 7HulklingS+100
  2. 15Nico MinoruS+100
  3. 21Spider-Woman (Jessica Drew)S+100
  4. 22Thanos (Deathless)S+100
  5. 25Black TarantulaS+96
  6. 32SandmanS+96

S Tier 6

  1. 38ScorpionconditionalS95
  2. 39SolvarchS95
  3. 55She-Hulk (Deathless)S88
  4. 56Arnim ZolaS87
  5. 60NimrodS86
  6. 65Yelena BelovaS86

A Tier 11

  1. 75HyperionA82
  2. 78SentinelA82
  3. 82Spider-Slayer (J. Jonah Jameson)A82
  4. 90Anti-VenomA78
  5. 92LizardA78
  6. 97She-HulkA78
  7. 100VoxA78
  8. 102DustA76
  9. 103MedusaA76
  10. 114Peni ParkerA72
  11. 117WarlockA72

B Tier 11

  1. 126HulkB68
  2. 128KindredB68
  3. 130Omega RedB68
  4. 135Viv VisionB68
  5. 141Black Widow (Claire Voyant)conditionalB64
  6. 142Emma FrostconditionalB64
  7. 152Phyla-VellB64
  8. 157The OverseerB64
  9. 158UltronB64
  10. 165Guillotine 2099B60
  11. 170Vision (Age of Ultron)B60

C Tier 11

  1. 172ArcadeconditionalC59
  2. 176Franken-CastleC59
  3. 178Joe FixitC59
  4. 179MaestroC59
  5. 183Cassie LangC58
  6. 187Hulk (Immortal)C56
  7. 194IcemanC54
  8. 200The LeaderC54
  9. 203Captain Marvel (Movie)C51
  10. 225RonanC47
  11. 232NebulaC46

D Tier 12

  1. 237MysterioD45
  2. 241Dragon ManD42
  3. 246The DestroyerD42
  4. 251Ms. MarvelD40
  5. 255Vision (Deathless)D39
  6. 257VisionD38
  7. 263ToadD36
  8. 265HobgoblinD34
  9. 270Ant-ManD32
  10. 274SauronD32
  11. 281Black BoltD30
  12. 284Ms. Marvel (Kamala Khan)D30

F Tier 8

  1. 287DarkhawkF28
  2. 292MephistoF28
  3. 295DormammuF26
  4. 296Hulk (Ragnarok)F26
  5. 306Red HulkF24
  6. 307AbominationF20
  7. 312Captain Marvel (Classic)F20
  8. 328Ultron (Classic)F20

Other immunities: Armor Break · Armor Shattered · Bleed · Buff Immunity · Coldsnap · Delirium · Fate Seal · Frostbite · Heal Block · Incinerate · Inverted Controls · Nullify · Power Burn · Power Drain · Power Lock · Power Steal · Regen Rate Mod · Rupture · Shock · Stagger